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Arsenic

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British Pharmacopoeia 1867

Preparations of Arsenic

Arsenious Acid / Acidum Arseniosum (syn: arsenicum album)[1]

  • “an anhydrous acid, obtained by roating arsenical orse, and purified by sublimation”
  • “occurs as a heavy white powder, or in sublimed masses which usually present a stratigied appearance caused by the existence of separated layers differing from each other in degrees of opacity”
  • given in dosages of 1/60 – 1/12 a grain, in a solution
  • used in the preparations of Liquor Arenicalis (4 grains in 1 fl oz) and in Liquor Arsenici Hydrochloricus (4 grains in 1 fluid oz)

Areseniate of Iron / Ferri Arsenian[2]

  • sulphate of iron (9 oz), Arsenitate of Soda, dried at 300° (4 oz), acetate of soda (3 oz), and boiling distilled water are combined to form…
  • “A tasteless amorphous powder of a green colour, insoluble in water, but reaily dissolved by hydrochloric acid.”
  • given in a dosage of 1/16 – ½ grains
  • also considered to be a preparation of iron [3]

Arsenical Solution / Liquor Arsenicalis (syn: Liquor Potasse Arsenitis, Fowler’s Solution”[4]

  • Arsenious Acid, in powder (80 grains), Carbonate of Potash (80 grains), Compound Ticture of Lavendar (5 fl drachms), and distilled water used to create
  • “a reddish liquid, alkaline to test paper, and having the odour of lavender”
  • given in a dose of 2-8 minims

Hydrochloric Solution of Arsenic / Liquor Arsenici Hydrochloricus [5]

  • Arsenious acid, in powder (80 grains), hydrochloric acid (2 fl drachms), and distilled water
  • “A colourless liquid, having an acid reaction.”
  • given in a dosage of 2-8 minims

Solution of Arseniate of Soda / Liquor Sodae Arseniatis[6]

  • Arseniate of Soda (rendered anhydrogenus by heat not exceeding 300°) (4 grains), dissolved in one fluid once of water

Arseniate of Soda / Sodae Arsenias[7]

  • Arsenious Acid (10 oz), Nitrate of Soda (8 ½ oz), dried carbonate of soda (5 ½ oz), and boiling distilled water (35 oz)
  • “In colourless transparent prisms soluble in water”
  • given in a dose of 1/16 – 1/8 grains
  • used in the preparation of Liquor Sodae Arseniatis (6.6 grains, or 4 grains dried) in 1 fl oz

A Compendium of Domestic Medicine, 1865

Savory warns those using arsenic, along with mercurial salts, digitalis, &c., that these products can accumulate in the system, and therefore should not be rapidly administered. [8] He Also notes that there is no known cure for arsenic poisoning, and as such, the stomach should be emptied immediately by use of sulphate of zinc.[9] However, arsenic "is a remedy of at least equal power with quinine," when treating ague, or intermittent fever. For this treatment, Fowler's Solution of Arsenic can be administered along with a dose of Jeremie's Solution of Opium. [10]

References

  1. General Medical Council of Great Britain, British Pharmacopeia, (London: Spottiswoode & Co.,1867), 6 https://archive.org/details/britishpharmacop00gene
  2. General Medical Council of Great Britain, British Pharmacopeia, (London: Spottiswoode & Co.,1867), 129-30 https://archive.org/details/britishpharmacop00gene
  3. GMCGB, 140
  4. GMCGB, 180-81
  5. GMCGB, 181-82
  6. GMCGB, 196
  7. GMCGB, 286
  8. Savory, John. A Compendium of Domestic Medicine (London: John Churchill and Sons, 1865), 21. https://books.google.ca/books?id=VxoDAAAAQAAJ&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
  9. Savory, 198
  10. Savory, 226


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